RNA Details
Disease Name
cystic fibrosis
Tissue
lung
RNA Symbol
IRF1
RNA ID
RNA Type
mRNA
Alteration Pattern
up regulation
Species
homo sapiens
Detection Methods
ELISA; qRT-PCR etc.
Target
IRF-1
Pathway
MIR-31/IRF-1/CTSS signaling pathway
PubMed ID
Title
MiR-31 dysregulation in cystic fibrosis airways contributes to increased pulmonary cathepsin S production
Year
2014
Function
"MiR-31, which is decreased in the CF airways, regulates IRF-1 in CF epithelial cells. Treating CF bronchial epithelial cells with a miR-31 mimic decreased IRF-1 protein levels with concomitant knockdown of CTSS expression and secretion."